Dynamic light scattering distributions by any means
نویسندگان
چکیده
Abstract Dynamic light scattering (DLS) is an essential technique for nanoparticle size analysis and has been employed extensively decades, but despite its long history popularity, the choice of weighting mean distribution often appears to be picked ad hoc bring results into agreement with other methods expectations by any means necessary . Here, we critically discuss application DLS characterization provide much-needed clarification ambiguities in mean-value practice commercial software documentary standards. We address misleading way distributions are presented, that is, as a logarithmically scaled histogram measured relative quantities. Central values obtained incautiously from this representation lead significant interpretation errors. Through measurement monomodal samples having extensive range sizes (5 250 nm) polydispersity, similarly demonstrate default outputs frequently used inversion method ill chosen, they regularizer-dependent significantly deviate cumulant z -average size. The resulting discrepancies typically larger than 15% depending on polydispersity index samples. explicitly identify validate harmonic central value intensity-weighted expresses consistently results. also investigate extent which descriptors representative distributional quality find them unreliable misleading, both monodisperse reference materials broad-distribution biomedical nanoparticles. These overall intended improvements stimulate reexamination metrological capabilities role characterization.
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ژورنال
عنوان ژورنال: Journal of Nanoparticle Research
سال: 2021
ISSN: ['1572-896X', '1388-0764']
DOI: https://doi.org/10.1007/s11051-021-05220-6